anti-FZD8 antibody (Frizzled Family Receptor 8) (N-Term)

Details for Product anti-FZD8 Antibody No. ABIN502083, Supplier: Login to see New
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Antigen
Synonyms FZ-8, FZD8, cFz-8, Fz-8, frizzled8, xfz8, Xfz8, frizzled-8, hfz8, hFZ8, fzd8, Fz8
Alternatives
Epitope
N-Term
(19), (15), (7), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(65), (33), (21), (3), (3), (1), (1)
Host
Rabbit
(48), (21), (3), (1)
Clonality
Polyclonal
Conjugate
This FZD8 antibody is un-conjugated
(3), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(52), (41), (24), (16), (7), (1), (1), (1)
Pubmed 2 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human FZD8
Blocking Peptide Blocking peptide for this product available: Frizzled Family Receptor 8 (FZD8) (N-Term) peptide (ABIN977174)
Sequence PDTLCMDYNR TDLTTAAPSP PRRLPPPPPG EQPPSGSGHG RPPGARPPHR
Predicted Reactivity Human : 100 %, Mouse : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against FZD8. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name FZD8 (FZD8 Antibody Abstract)
Background FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Molecular Weight 73 kDa
Gene ID 8325
NCBI Accession NP_114072, NM_031866
UniProt Q9H461
Pathways WNT Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 694 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-FZD8 antibody (Frizzled Family Receptor 8) (N-Term) (ABIN502083) WB Suggested Anti-FZD8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Product cited in: Yin, Xu, Bonfil et al.: "Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer." in: Molecular cancer therapeutics, Vol. 12, Issue 4, pp. 491-8, 2013 (PubMed).

Background publications Lu, Yamamoto, Ortega et al.: "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth." in: Cell, Vol. 119, Issue 1, pp. 97-108, 2004 (PubMed).

Catalog No. ABIN502083
$289.00
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