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Details for Product No. ABIN502083

Frizzled Family Receptor 8 (FZD8) (N-Term) antibody

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Antigen
Synonyms FZ-8, hFZ8, Xfz8, frizzled8, fzd8, FZD8, cFz-8, Fz-8, xfz8, frizzled-8, hfz8
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN502083
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-FZD8 antibody: synthetic peptide directed towards the N terminal of human FZD8
Sequence PDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHG RPPGARPPHR
Predicted Reactivity Human : 100%, Mouse : 92%, Rat : 92%
Characteristics This is a rabbit polyclonal antibody against FZD8. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name FZD8
Background FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Molecular Weight 73kDa
Gene ID 8325
NCBI Accession NP_114072, NM_031866
UniProt Q9H461
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-FZD8 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Lu, Yamamoto, Ortega et al.: "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth." in: Cell, Vol. 119, Issue 1, pp. 97-108, 2004 (PubMed).

Alternatives for antigen "Frizzled Family Receptor 8 (FZD8)", type "Antibodies"
Hosts (45), (9), (1), (1)
Reactivities (49), (39), (32), (18), (2)
Applications (32), (24), (16), (15), (10), (4), (4)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (5), (4), (1), (1), (1)
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