Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (N-Term) antibody

Details for Product No. ABIN502194
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Antigen
Synonyms CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, CXC-R2, CXCR-2, CD128, CDw128, Cmkar2, Gpcr16, IL-8Rh, IL-8rb, Il8rb, mIL-8RH
Epitope
N-Term
(19), (14), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(120), (37), (34), (24), (12), (12), (12), (1)
Host
Rabbit
(91), (32), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(51), (46), (32), (30), (21), (12), (10), (10), (9), (7), (6), (4), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN502194
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human IL8RB
Sequence MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF
Predicted Reactivity Chimpanzee :100 %,   Human :100 %,   Lowland gorilla :90 %,   Bornean orangutan :90 %,   Western Gorilla :90 %,  
Characteristics This is a rabbit polyclonal antibody against IL8RB. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name IL8RB
Background IL8RB is the receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. IL8RB binds to IL-8 with high affinity. IL8RB also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
Molecular Weight 41 kDa
Gene ID 3579
NCBI Accession NP_001548, NM_001557
UniProt P25025
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 360 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (N-Term) antibody WB Suggested Anti-IL8RB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: PANC1 cell lysate
Background publications Gauvreau, Boulet, Cockcroft et al.: "Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses." in: American journal of respiratory and critical care medicine, Vol. 177, Issue 9, pp. 952-8, 2008 (PubMed).

Validation Images
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