Flavin Containing Monooxygenase 4 (FMO4) (N-Term) antibody

Details for Product No. ABIN502600
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Antigen
Synonyms FMO2, D1Ertd532e
Epitope
N-Term
(2), (2), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Dog (Canine), Human
(7), (3), (1)
Host
Rabbit
(7), (2)
Clonality
Polyclonal
Application
Western Blotting (WB)
(9), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN502600
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Immunogen Synthetic peptide directed towards the N terminal of human FMO4
Sequence MVCTGHFLNP HLPLEAFPGI HKFKGQILHS QEYKIPEGFQ GKRVLVIGLG
Predicted Reactivity Bovine : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Dog : 80 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against FMO4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name FMO4
Background FMO4 belongs to the FMO family. Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
Molecular Weight 63 kDa
Gene ID 2329
NCBI Accession NP_002013, NM_002022
UniProt P31512
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 558 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Flavin Containing Monooxygenase 4 (FMO4) (N-Term) antibody WB Suggested Anti-FMO4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
anti-Flavin Containing Monooxygenase 4 (FMO4) (N-Term) antibody (2) Host: Rabbit
Target Name: FMO4
Sample Tissue: Human Fetal Heart
Antibody Dilution: 1.0 µg/mL
anti-Flavin Containing Monooxygenase 4 (FMO4) (N-Term) antibody (3) Host: Rabbit
Target Name: FMO4
Sample Tissue: Human Fetal Lung
Antibody Dilution: 1.0 µg/mL
Background publications Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

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