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SIGLEC10 antibody (Middle Region)

This Rabbit Polyclonal antibody specifically detects SIGLEC10 in WB. It exhibits reactivity toward Human and Dogand has been mentioned in 1 publication.
Catalog No. ABIN503134

Quick Overview for SIGLEC10 antibody (Middle Region) (ABIN503134)

Target

See all SIGLEC10 Antibodies
SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Reactivity

  • 54
  • 2
  • 1
  • 1
Human, Dog

Host

  • 40
  • 15
  • 1
Rabbit

Clonality

  • 41
  • 15
Polyclonal

Conjugate

  • 25
  • 9
  • 7
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This SIGLEC10 antibody is un-conjugated

Application

  • 36
  • 27
  • 16
  • 8
  • 8
  • 7
  • 3
  • 2
Western Blotting (WB)
  • Binding Specificity

    • 8
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequence

    CHVDFSRKGV SAQRTVRLRV AYAPRDLVIS ISRDNTPALE PQPQGNVPYL

    Predicted Reactivity

    Dog: 79%, Human: 100%

    Characteristics

    This is a rabbit polyclonal antibody against SIGLEC10. It was validated on Western Blot using a cell lysate as a positive control.

    Purification

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC10
  • Application Notes

    Optimal working dilutions should be determined experimentally by the investigator.

    Comment

    Antigen size: 697 AA

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." in: Genome biology, Vol. 8, Issue 8, pp. R154, (2008) (PubMed).

  • Target

    SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

    Alternative Name

    SIGLEC10

    Background

    SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SIGLEC10 preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC10 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-653 AC008750.9 90495-91147 c 654-760 DA387605.1 391-497 761-2959 AF301007.1 262-2460 2960-3794 AY358337.1 1930-2764
    Alias Symbols: MGC126774, PRO940, SIGLEC-10, SLG2
    Protein Interaction Partner: FLNA, PTPN6,
    Protein Size: 697

    Molecular Weight

    76 kDa

    Gene ID

    89790

    NCBI Accession

    NM_033130, NP_149121

    UniProt

    Q96LC7
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