SIGLEC10 antibody (AA 321-420)

Catalog No. ABIN749423

The Rabbit Polyclonal anti-SIGLEC10 antibody is suitable to detect SIGLEC10 in samples from Human. It has been validated for WB.

Quick Overview for SIGLEC10 antibody (AA 321-420) (ABIN749423)

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGLEC10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIGLEC10 Antibody

Binding Specificity: AA 321-420

Purpose: SIGLEC10 Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SIGLEC10

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SIGLEC10

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Alternative Name: SIGLEC10

Background:

Synonyms: PRO940, mSiglec G, Sialic acid binding Ig like lectin 10, Sialic acid binding Ig like lectin 10, sialic acid binding Ig like lectin 10 Ig like lectin 7, sialic acid binding Ig like lectin G, Sialic acid binding Immunoglobulin like lectin 10, SIGLEC 10, Siglec G, siglec like gene 2, Siglec like protein 2, Siglec like protein 2, Siglecg, SLG2.

Background: SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC10 interacts with PTPN6/SHP-1 upon phosphorylation. The protein is expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation).

Gene ID: 89790

UniProt: Q96LC7