Transmembrane Protease, serine 6 (TMPRSS6) (N-Term) antibody

Details for Product No. ABIN503447
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Antigen
Synonyms IRIDA, 1300008A22Rik
Epitope
N-Term
(9), (7), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(30), (20), (20), (17), (17), (17)
Host
Rabbit
(29), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(16), (14), (8), (4), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN503447
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human TMPRSS6
Sequence LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK
Predicted Reactivity Human : 100 %, Rat : 100 %, Dog : 90 %, Guinea pig : 80 %
Characteristics This is a rabbit polyclonal antibody against TMPRSS6. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TMPRSS6
Background TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Molecular Weight 90 kDa
Gene ID 164656
NCBI Accession NP_705837, NM_153609
UniProt Q8IU80
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 811 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Transmembrane Protease, serine 6 (TMPRSS6) (N-Term) antibody WB Suggested Anti-TMPRSS6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate
anti-Transmembrane Protease, serine 6 (TMPRSS6) (N-Term) antibody (2) anti-Transmembrane Protease, serine 6 (TMPRSS6) (N-Term) antibody (Image 2)
Background publications Finberg, Heeney, Campagna et al.: "Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)." in: Nature genetics, Vol. 40, Issue 5, pp. 569-71, 2008 (PubMed).

Validation Images
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