ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) (ATG4B) (N-Term) antibody

Details for Product No. ABIN504365
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Antigen
Synonyms apg4b, APG4B, AUTL1, 2510009N07Rik, AW048066, Apg4b, Atg4bl, Autl1, Aut2b2
Epitope
N-Term
(15), (8), (7), (7), (6), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Cow (Bovine), Pig (Porcine), Human, Chicken
(81), (34), (17), (14), (13), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(78), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(69), (34), (28), (14), (10), (2), (2), (2), (2), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN504365
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human ATG4B
Sequence WGCMLRCGQM IFAQALVCRH LGRDWRWTQR KRQPDSYFSV LNAFIDRKDS
Predicted Reactivity Guinea pig : 100 %, Human : 100 %, Rat : 100 %, Bovine : 90 %, Dog : 90 %, Mouse : 90 %, Pig : 80 %, Rabbit : 80 %, Chicken : 80 %
Characteristics This is a rabbit polyclonal antibody against ATG4B. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ATG4B
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. ATG4B is a member of the autophagin protein family, it is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Molecular Weight 44 kDa
Gene ID 23192
NCBI Accession NP_037457, NM_013325
UniProt Q9Y4P1
Research Area Cancer, Autophagy, Proteolysis / Ubiquitin
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 393 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) (ATG4B) (N-Term) antibody WB Suggested Anti-ATG4B Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Placenta
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Validation Images
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