TRPC3 antibody (N-Term)

Catalog No. ABIN504516

The Rabbit Polyclonal anti-TRPC3 antibody (ABIN504516) specifically detects TRPC3 in WB. The antibody is reactive with Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig and Zebrafish (Danio rerio) samples.

Quick Overview for TRPC3 antibody (N-Term) (ABIN504516)

Target: TRPC3 (Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPC3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRPC3 Antibody

Binding Specificity: N-Term

Sequence: MEGSPSLRRM TVMREKGRRQ AVRGPAFMFN DRGTSLTAEE ERFLDAAEYG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against TRPC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of human TRPC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 848 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRPC3

Target: TRPC3 (Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3))

Alternative Name: TRPC3

Background: TRPC3 is thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC3 is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. TRPC3 may also be activated by internal calcium store depletion.
Alias Symbols: TRP3
Protein Interaction Partner: STX3, TRPC1, PRKG1, ORAI1, PLCB1, PLCB2, TRPC6, NAPA, PLCB3, FKBP1A, VAMP2, SLC8A1, PRKCA, PLCG1, ITPR3, ITPR1, MX1, GNA11, CALM1, TRPC7, TRPC3, TRPC5, TRPC4,
Protein Size: 848

Molecular Weight: 97 kDa

Gene ID: 7222

NCBI Accession: NM_003305, NP_003296

UniProt: Q13507