LRPPRC antibody (AA 1203-1236)

Catalog No. ABIN5536608

Product Details anti-LRPPRC Antibody

Target: LRPPRC (Leucine-Rich PPR-Motif Containing (LRPPRC))

Binding Specificity: AA 1203-1236

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRPPRC antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LRPPRC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1203-1236 amino acids from human LRPPRC.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LRPPRC

Target: LRPPRC (Leucine-Rich PPR-Motif Containing (LRPPRC))

Alternative Name: LRPPRC (LRPPRC Products)

Synonyms: CLONE-23970 antibody, GP130 antibody, LRP130 antibody, LSFC antibody, Lrp157 antibody, 3110001K13Rik antibody, C76645 antibody, Gp130 antibody, Lrp130 antibody, Lsfc antibody, leucine rich pentatricopeptide repeat containing antibody, leucine-rich pentatricopeptide repeat containing antibody, leucine-rich PPR-motif containing antibody, LRPPRC antibody, Lrpprc antibody

Background: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).

Molecular Weight: 158 kDa

Gene ID: 10128

UniProt: P42704