POF1B antibody (AA 337-366)

Catalog No. ABIN5538624

Product Details anti-POF1B Antibody

Target: POF1B (Premature Ovarian Failure, 1B (POF1B))

Binding Specificity: AA 337-366

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POF1B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This POF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the Central region of human POF1B.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for POF1B

Target: POF1B (Premature Ovarian Failure, 1B (POF1B))

Alternative Name: POF1B (POF1B Products)

Synonyms: RGD1560798 antibody, 2310066B14Rik antibody, POF antibody, POF2B antibody, POF1B, actin binding protein antibody, premature ovarian failure 1B antibody, Pof1b antibody, POF1B antibody

Background: Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called 'POF1' and 'POF2' have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.

Molecular Weight: 68 kDa

Gene ID: 79983

UniProt: Q8WVV4