WIPI2 antibody (N-Term)

Catalog No. ABIN1450025

Product Details anti-WIPI2 Antibody

Target: WIPI2 (WD Repeat Domain, Phosphoinositide Interacting 2 (WIPI2))

Binding Specificity: N-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WIPI2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: A 17 amino acid peptide near the amino terminus of human WIPI2.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for WIPI2

Target: WIPI2 (WD Repeat Domain, Phosphoinositide Interacting 2 (WIPI2))

Alternative Name: WIPI-2 (WIPI2 Products)

Synonyms: ATG18B antibody, Atg21 antibody, WIPI-2 antibody, 1110018O08Rik antibody, 2510001I10Rik antibody, WD repeat domain, phosphoinositide interacting 2 L homeolog antibody, WD repeat domain, phosphoinositide interacting 2 antibody, wipi2.L antibody, WIPI2 antibody, Wipi2 antibody

Background: WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.Synonyms: CGI-50, WD repeat domain phosphoinositide-interacting protein 2, WIPI2, WIPI49-like protein 2

Molecular Weight: 50 kDa

Gene ID: 26100

NCBI Accession: NP_056425