HIP1 antibody (AA 928-1037)

Catalog No. ABIN561263

There are 7+ publications for this product available. The Mouse Monoclonal anti-HIP1 antibody is suitable to detect HIP1 in samples from Human. It has been validated for WB, ELISA, IP and IHC (p).

Quick Overview for HIP1 antibody (AA 928-1037) (ABIN561263)

Target: HIP1 (Huntingtin Interacting Protein 1 (HIP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HIP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1F12

Product Details anti-HIP1 Antibody

Binding Specificity: AA 928-1037

Purpose: Mouse monoclonal antibody raised against a partial recombinant HIP1.

Sequence: DSPNLAQLQQ ASRGVNQATA GVVASTISGK SQIEETDNMD FSSMTLTQIK RQEMDSQVRV LELENELQKE RQKLGELRKK HYELAGVAEG WEEGTEASPP TLQEVVTEKE

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: HIP1 (NP_005329, 928 a.a. ~ 1037 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-HIP1 antibody (ABIN561263)

Peng: "The T-box transcription factor T-bet in immunity and autoimmunity." in: Cellular & molecular immunology, Vol. 3, Issue 2, pp. 87-95, (2006) (PubMed).

Hwang, Hong, Glimcher: "IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508." in: The Journal of experimental medicine, Vol. 202, Issue 9, pp. 1289-300, (2005) (PubMed).

Townsend, Weinmann, Matsuda, Salomon, Farnham, Biron, Gapin, Glimcher: "T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells." in: Immunity, Vol. 20, Issue 4, pp. 477-94, (2004) (PubMed).

Hibbert, Pflanz, De Waal Malefyt, Kastelein: "IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 23, Issue 9, pp. 513-22, (2003) (PubMed).

Peng, Szabo, Glimcher: "T-bet regulates IgG class switching and pathogenic autoantibody production." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5545-50, (2002) (PubMed).

Zhang, Yang: "Cloning and characterization of a new member of the T-box gene family." in: Genomics, Vol. 70, Issue 1, pp. 41-8, (2001) (PubMed).

Szabo, Kim, Costa, Zhang, Fathman, Glimcher: "A novel transcription factor, T-bet, directs Th1 lineage commitment." in: Cell, Vol. 100, Issue 6, pp. 655-69, (2000) (PubMed).

Target Details for HIP1

Target: HIP1 (Huntingtin Interacting Protein 1 (HIP1))

Alternative Name: HIP1

Background: Full Gene Name: huntingtin interacting protein 1
Synonyms: ILWEQ,MGC126506

Gene ID: 3092

NCBI Accession: NM_005338

Pathways: Positive Regulation of Endopeptidase Activity