GZMA antibody (C-Term)

Catalog No. ABIN567306

This anti-GZMA antibody is a Rabbit Polyclonal antibody detecting GZMA in WB. Suitable for Human, Rat, Dog and Guinea Pig.

Quick Overview for GZMA antibody (C-Term) (ABIN567306)

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Reactivity: Human, Rat, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GZMA Antibody

Binding Specificity: C-Term

Sequence: LRGGRDSCNG DSGSPLLCEG VFRGVTSFGL ENKCGDPRGP GVYILLSKKH

Predicted Reactivity: Dog: 82%, Guinea Pig: 90%, Human: 100%, Rat: 75%

Characteristics: This is a rabbit polyclonal antibody against GZMA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GZMA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 262 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GZMA

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Alternative Name: GZMA

Background: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.
Alias Symbols: CTLA3, HFSP
Protein Interaction Partner: HSP90AA1, HSPA4, HMGB2, APEX1, XRCC5, XRCC6, HIST2H2BE, SET, LMNA, HNRNPK, HDC, HIST1H1A, GZMA, GOLGA2, ACTG1, Ndufs3, NCL, LMNB1,
Protein Size: 262

Molecular Weight: 26 kDa

Gene ID: 3001

NCBI Accession: NM_006144, NP_006135

UniProt: P12544

Pathways: Apoptosis