HLA-DQA2 antibody (C-Term)

Catalog No. ABIN569593

Product Details anti-HLA-DQA2 Antibody

Target: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This HLA-DQA2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-QGLRSVGASR H

Specificity: This antibody is expected to recognize: HLA-DQA2 (NP_064440.1) and also the very similar HLA-DQA1 (NP_002113.2).

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of Human HLADQA1 + HLADQA2 (NP_064440.1, NP_002113.2).

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HLA-DQA2

Target: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Alternative Name: HLA-DQA2 (HLA-DQA2 Products)

Synonyms: DX-ALPHA antibody, HLA-DXA antibody, major histocompatibility complex, class II, DQ alpha 2 antibody, HLA-DQA2 antibody

Background: HLADQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). HLADQA2 forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site.Synonyms: DX alpha chain, HLA class II histocompatibility antigen DQ alpha 2 chain, HLA class II histocompatibility antigen DQ(6) alpha chain, HLA-DQA1, HLA-DXA, MHC class II DQA2

Gene ID: 3118

NCBI Accession: NP_064440

UniProt: P01906

Pathways: TCR Signaling