CD45 antibody (FITC)

Catalog No. ABIN610105

This Mouse Monoclonal antibody specifically detects CD45 in FACS. It exhibits reactivity toward Human. It has been mentioned in 4+ publications

Quick Overview for CD45 antibody (FITC) (ABIN610105)

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD45 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Clone: C11

Product Details anti-CD45 Antibody (FITC)

Specificity: All isoforms of CD45.

Purification: Protein A purified

Immunogen: Peripheral blood mononuclear cells.

Type of Immunogen: Cells

Isotype: IgG2a kappa

Application Details

Application Notes: Approved: Flo

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 5 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze. Product is photosensitive and should be protected from light.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Protect from light.

References for anti-CD45 antibody (FITC) (ABIN610105)

Clark, Hynes: "Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14814-8, (1996) (PubMed).

Milasincic, Calera, Farmer, Pilch: "Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways." in: Molecular and cellular biology, Vol. 16, Issue 11, pp. 5964-73, (1996) (PubMed).

Sauma, Friedman: "Increased expression of protein kinase C beta activates ERK3." in: The Journal of biological chemistry, Vol. 271, Issue 19, pp. 11422-6, (1996) (PubMed).

Cobb, Goldsmith: "How MAP kinases are regulated." in: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 14843-6, (1995) (PubMed).

Target Details for CD45

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Alternative Name: CD45

Background: Name/Gene ID: PTPRC
Subfamily: R1/R6
Family: Protein Phosphatase

Synonyms: PTPRC, B220, CD45R, CD45, gp180, Leukocyte common antigen, L-CA, Leucocyte common antigen, LY5, T200, T200 glycoprotein, T200 leukocyte common antigen, CD45 antigen, LCA

Gene ID: 5788

UniProt: P08575

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling