CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C) (AA 928-989)

Details for Product anti-PTPRC Antibody No. ABIN1724924
Antigen
Epitope
AA 928-989
32
19
16
16
16
15
15
14
12
10
9
8
6
5
5
5
5
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
1235
555
143
77
52
40
36
29
19
14
13
13
9
8
7
4
4
3
3
2
1
1
1
1
Host
Mouse
1155
539
287
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD45 antibody is un-conjugated
237
207
137
122
45
25
24
23
23
22
18
15
14
14
11
11
10
10
10
10
10
9
8
8
7
7
7
7
7
7
7
7
7
7
7
7
7
6
5
5
5
5
5
4
4
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
1634
597
415
397
322
264
207
110
76
74
52
36
32
16
8
4
4
3
3
3
3
2
2
2
1
1
Options
Immunogen Purified recombinant fragment of human PTPRC (AA 928-989) expressed in E. Coli.
Clone 5D3A3
Isotype IgG1
Purification Purified
Antigen
Alternative Name PTPRC (PTPRC Antibody Abstract)
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. , , ,
Molecular Weight 147.3 kDa
Gene ID 5788
HGNC 5788
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 928-989) antibody (ABIN1724924) Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using PTP...
Image no. 2 for anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 928-989) antibody (ABIN1724924) Immunohistochemical analysis of paraffin-embedded breast cancer tissues using PTPRC m...
Product cited in: Pujari, Eligar, Kumar, Nagre, Inamdar, Swamy, Shastry: "CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin (RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC." in: Biochemical and biophysical research communications, Vol. 419, Issue 4, pp. 708-14, 2012 (PubMed).

Gopal, Pagel, Fromm, Wilbur, Press: "131I anti-CD45 radioimmunotherapy effectively targets and treats T-cell non-Hodgkin lymphoma." in: Blood, Vol. 113, Issue 23, pp. 5905-10, 2009 (PubMed).