PDIA4 antibody (AA 623-638)

Catalog No. ABIN615311

The Rabbit Polyclonal anti-PDIA4 antibody is suitable to detect PDIA4 in samples from Mouse. It has been validated for WB and IHC (p).

Quick Overview for PDIA4 antibody (AA 623-638) (ABIN615311)

Target: PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDIA4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PDIA4 Antibody

Binding Specificity: AA 623-638

Specificity: This antibody reacts to Protein Disulfide Isomerase Family A, Member 4 (PDIA4).

Cross-Reactivity (Details): Species reactivity (expected):Bovine, Canine, Guinea pig, Hamster, Human, Monkey, Rabbit, Rat.
Species reactivity (tested):Mouse.

Purification: Protein A Chromatography

Immunogen: PDIA4 antibody was raised against a synthetic peptide based on the sequence of mouse ERp72 (residues 623-638) with a cysteine residue added and coupled to KLH.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.09 % azide and 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for PDIA4

Target: PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))

Alternative Name: PDIA4

Background: Endoplasmic reticulum protein (ERp) 72 is a member of the protein disulfide isomerase (PDI) family1 that is localized to the endoplasmic reticulum. It contains three repeats of the thioredoxin-like regions that is postulated to represent three independently acting catalytic domains (CGHC) of PDI activity. ERp72 contains the sequence at its carboxyl terminus which serves as its ER retention signal. Together with other ER resident proteins such as BiP, GRP94, and PDI, they serve as the molecular chaperones for proper folding of newly translocated and glycolsylated proteins such as thyroglobulin (Tg) and human chorionic gonadotropin (hCG)-b. ERp72 expression is regulated by the level of misfolding proteins in the ER, as the amount of ERp72 increased in response to epithelial ischemia, a condition that perturbs the maturation of secretory proteins.Synonyms: ER marker, ER protein 70, ER protein 72, ERP70, ERP72, ERp-70, ERp-72, Endoplasmic reticulum resident protein 70, Endoplasmic reticulum resident protein 72, Protein Disulfide Isomerase, Protein disulfide-isomerase A4

Gene ID: 9601

NCBI Accession: NP_004902

UniProt: P13667

Pathways: Thyroid Hormone Synthesis, Cell RedoxHomeostasis