IRAK4 antibody (N-Term)

Catalog No. ABIN615818

The Goat Polyclonal anti-IRAK4 antibody is suitable to detect IRAK4 in samples from Human, Mouse and Monkey. It has been validated for WB, IHC (p) and EIA.

Quick Overview for IRAK4 antibody (N-Term) (ABIN615818)

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reactivity: Human, Mouse, Monkey

Host: Goat

Clonality: Polyclonal

Conjugate: This IRAK4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-IRAK4 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to the N-Terminus of Interleukin 1 Receptor-Associated Kinase 4 (IRAK4) - (peptide sequence (NKPITPSTYVRC))

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide - KLH conjugated Genename: IRAK4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Tris buffered saline containing 0.5 % BSA as stabilizer and 0.02 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for IRAK4

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Alternative Name: IRAK4

Background: IRAK4, an IRAK type protein kinase, is a signal transducer for the immune response Toll-like receptor and interleukin-1 (IL-1) receptor signaling cascades. IRAK4 has auto- and cross-phosphorylation kinase activity and has been shown to phosphorylate and activate IRAK1. Additionally, IRAK4 interacts with IRAK1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK4 can activate NF-kappaB as well as mitogen-activated protein (MAP) kinase pathways. IRAK4 (-/-) mice are resistant to a lethal dose of lipopolysaccharide and are severely impaired in their responses to viral and bacterial challenges. At least two mRNA transcripts have been reported: 3.0- and 4.4-kb. IRAK4, also referrred to as NY-REN-64, was first identified as an antigen in a screen of renal tumors.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64

Gene ID: 51135

NCBI Accession: NP_001107654

UniProt: Q9NWZ3

Pathways: NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades