Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (C-Term) antibody

Details for Product No. ABIN615985
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Antigen
Synonyms TIH1, Tih1, si:dz182n13.5, zgc:92333
Epitope
C-Term
(3), (3), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(16), (10), (9)
Host
Goat
(12), (4)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(12), (7), (4), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN615985
357.50 $
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Immunogen synthetic peptide corresponding to the C Terminus of the protein sequence of Huuman PHLDA3 (NP_036528.1). Genename: PHLDA3
Sequence C-RARQSLGTGT LVS
Specificity Recognizes PHLDA3 / TIH1
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Alternative Name PHLDA3
Background P53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.
Alternate names: Pleckstrin homology-like domain family A member 3, TDAG51/Ipl homologue 1, TIH1
Gene ID 23612
NCBI Accession NP_036528
UniProt Q9Y5J5
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Frank, Mendelsohn, Ciccone et al.: "A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 10, Issue 12, pp. 1150-9, 2000 (PubMed).

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