CYP24A1 antibody (C-Term)

Catalog No. ABIN617271

The Rabbit Polyclonal anti-CYP24A1 antibody (ABIN617271) specifically detects CYP24A1 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Rabbit and Guinea Pig samples.

Quick Overview for CYP24A1 antibody (C-Term) (ABIN617271)

Target: CYP24A1 (Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP24A1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CYP24A1 Antibody

Binding Specificity: C-Term

Sequence: QVLGSSEDNF EDSSQFRPER WLQEKEKINP FAHLPFGVGK RMCIGRRLAE

Predicted Reactivity: Dog: 79%, Guinea Pig: 86%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against CYP24A1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CYP24A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 514 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CYP24A1

Target: CYP24A1 (Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1))

Alternative Name: CYP24A1

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CP24, CYP24, MGC126273, MGC126274, P450-CC24, HCAI
Protein Interaction Partner: Dlg4, UBC,
Protein Size: 514

Molecular Weight: 55 kDa

Gene ID: 1591

NCBI Accession: NM_000782, NP_000773

UniProt: Q07973

Pathways: Metabolism of Steroid Hormones and Vitamin D