Ensa antibody (AA 1-121) (HRP)

Catalog No. ABIN618461

The Rabbit Polyclonal anti-Ensa antibody is suitable to detect Ensa in samples from Human. It has been validated for ELISA.

Quick Overview for Ensa antibody (AA 1-121) (HRP) (ABIN618461)

Target: Ensa (ENSA) (Endosulfine alpha (ENSA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ensa antibody is conjugated to HRP

Application: ELISA

Product Details anti-Ensa Antibody (HRP)

Binding Specificity: AA 1-121

Purpose: ENSA Antibody, HRP conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Alpha-endosulfine protein (1-121AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.
Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Ensa

Target: Ensa (ENSA) (Endosulfine alpha (ENSA))

Alternative Name: ENSA

Background:

Background: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

Aliases: ENSAAlpha-endosulfine antibody, ARPP-19e antibody

UniProt: O43768