Ensa antibody (N-Term)

Catalog No. ABIN2785426

The Rabbit Polyclonal anti-Ensa antibody (ABIN2785426) specifically detects Ensa in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Pig and Rabbit samples.

Quick Overview for Ensa antibody (N-Term) (ABIN2785426)

Target: Ensa (ENSA) (Endosulfine alpha (ENSA))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ensa antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Ensa Antibody

Binding Specificity: N-Term

Purpose: ENSA Antibody - N-terminal region

Sequence: MAGGLGCDVC YWFVEDTQEK EGILPERAEE AKLKAKYPSL GQKPGGSDFL

Predicted Reactivity: Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against ENSA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ENSA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP53514-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Ensa

Target: Ensa (ENSA) (Endosulfine alpha (ENSA))

Alternative Name: ENSA

Background:

Background Information: The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene Name: Endosulfine alpha

Alternative Symbols: ARPP-19e

Protein Name: Alpha-endosulfine

Molecular Weight: 12

Gene ID: 2029

NCBI Accession: NP_996930

UniProt: O43768