MICA/B antibody

Catalog No. ABIN642842

The Mouse Monoclonal anti-MICA/B antibody is suitable to detect MICA/B in samples from Human. It has been validated for FACS, IHC (fro), IP and Func.

Quick Overview for MICA/B antibody (ABIN642842)

Target: MICA/B (MICA/MICB) (MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MICA/B antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Functional Studies (Func)

Product Details anti-MICA/B Antibody

Purpose: Mouse Anti-Human MICA+MICB

Specificity: DS-MB-01916 is specific for nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB). MICA and MICB are stress inducible antigens, which are closely related and appear functionally indistinguishable. MICA and MICB are ligands for NKG2D, an activating receptor on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. MICA is principally expressed on intestinal epithelium, and several epithelial tumours. Expression may be induced to high surface levels by heat shock, oxidative stress, and virus infection. DS-MB-01916 is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells (6).

Characteristics: MHC Class

Endotoxin Level: <0.01 EU/mg

Immunogen: MICA transfected C1R cells

Isotype: IgG2a

Application Details

Application Notes: Immunohistology - Frozen, Flow Cytometry, Functional Assays, Immunoprecipitation

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline pH7.4

Storage: -20 °C

Storage Comment: -20°C

Target Details for MICA/B

Target: MICA/B (MICA/MICB) (MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB))

Alternative Name: MICA/MICB