Caspase 7 antibody (C-Term)

Catalog No. ABIN644997

The Rabbit Polyclonal anti-Caspase 7 antibody (ABIN644997) specifically detects Caspase 7 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Caspase 7 antibody (C-Term) (ABIN644997)

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Caspase 7 Antibody

Binding Specificity: C-Term

Purpose: Rabbit Anti-Human CASP7 (C-term)

Specificity: DS-PB-00381 recognizes an epitope within the C-terminal region (CT) of Caspase7, a 35kDa cysteine protease, otherwise known as ICE like Apoptotic Protease 3 (ICELAP3). Caspase7, a member of the ICE/Ced3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase7 occurs during cell death induced by the cytokine death receptors Fas/APO1 and the receptor of tumor necrosis factor (TNFR1), coupled with the fact that granzymeB activated Caspase7 cleaves the nuclear enzyme poly (ADPribose) polymerase (PARP), suggests an important role for Caspase7 in both cytokinemediated and GranzymeB mediated apoptosis pathways.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Characteristics: Phosphorylation/Apoptosis/Signal Transduction/Regulation

Purification: Purified

Immunogen: Antisera to human Caspase-7 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Isotype: IgG

Application Details

Application Notes: Immunohistology - Paraffin, Western Blotting

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

Target Details for Caspase 7

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Alternative Name: Caspase-7

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity