V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) antibody

Antigen: V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3)

Synonyms: ERBB3

Host: Goat

Catalog no.: ABIN645836

Additional Information

Characteristics: Goat Anti-ERBB3 / HER3, with HRP-conjugated secondary antibody

Alternative name: ERBB3 / HER3

Swiss-Prot: NP_001973.2.

Immunogen: Peptide with sequence -HSRLFPKANAQRT, from the C-terminus of the protein sequence according to NP_001973.2. was used as immunogen.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Reconstitution: Supplied as 100 µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Isotype: IgG  (Matching secondary antibodies)

Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is detected at 180 kDa by SDS-PAGE and is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form of 85 kDa which negatively regulates heregulin-stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

Specificity: The ErbB3 goat antibody detects protein derived from human, Jurkat cell lysate at various concentrations.

Application Details

Components: HRP-conjugated secondary antibody provided along with this antibody

Storage: Store at -20 ° C, if not intended for use within a month, Keep it at 4 ° C and minimize freezing and thawing when use.

Restrictions: For Research Use only