KAP1 antibody

Catalog No. ABIN645876

The Goat not_set anti-KAP1 antibody (ABIN645876) specifically detects KAP1. The antibody is reactive with Human and Mouse samples.

Quick Overview for KAP1 antibody (ABIN645876)

Target: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Reactivity: Human, Mouse

Host: Goat

Conjugate: This KAP1 antibody is un-conjugated

Application: Please inquire

Product Details anti-KAP1 Antibody

Specificity: The Goat anti-KAP1 / TRIM28 antibody detects protein derived from human recombinant protein and HepG2 lysate at various concentrations.

Cross-Reactivity: Human, Mouse (Murine)

Characteristics: Goat Anti-KAP1 / TRIM28

Immunogen: Peptide with sequence C-SSQELSGGPGDGP, from the C Terminus of the protein sequence according to NP_005753, was used as an immunogen.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Reconstitution: Supplied as 100µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Storage: -20 °C

Target Details for KAP1

Target: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Alternative Name: KAP1 / TRIM28

Background: KAP1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger. KAP1 has been shown to form complexes with KRAB domain transcription factors and increase the efficiency with which they mediate repression. KAP1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel associated box containing zinc finger protein 1). KAP1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, helping to regulate transcriptional repression. Recent studies have shown that KAP1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.

NCBI Accession: NP_005753

Pathways: Hedgehog Signaling, Positive Regulation of Response to DNA Damage Stimulus