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BCL2-Related Protein A1 (BCL2A1) (AA 53-81), (Center) antibody

Details for Product No. ABIN650621
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Antigen
Synonyms BCL2A1, A1, BB218357, Bcl2a1, Bfl-1, Hbpa1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1, Bcl2a1d
Epitope
AA 53-81, Center
(18), (10), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(62), (37), (28), (1), (1), (1), (1)
Host
Rabbit
(59), (4), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(55), (30), (20), (13), (10), (4), (3), (2), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN650621
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Immunogen This BCL2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 AA from the Central region of human BCL2A1.
Clone RB16877
Isotype Ig
Specificity This BCL2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63~92 amino acids from the Center region of human BCL2A1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name BCL2A1
Background Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
Synonyms: Human Bcl2-related Protein A1, BFL1, Hematopoietic-specific early response protein, GRS protein
Molecular Weight 20132 DA
Gene ID 597
UniProt Q16548
Research Area Apoptosis/Necrosis, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-BCL2-Related Protein A1 (BCL2A1) (AA 53-81), (Center) antibody Western blot analysis of BCL2A1 Antibody (Center) (ABIN650621) in T47D cell line lysates (35 µg/lane). BCL2A1 (arrow) was detected using the purified polyclonal antibody.
anti-BCL2-Related Protein A1 (BCL2A1) (AA 53-81), (Center) antibody (2) Formalin-fixed and paraffin-embedded human lung carcinoma reacted with BCL2A1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-BCL2-Related Protein A1 (BCL2A1) (AA 53-81), (Center) antibody (3) BCL2A1 Antibody (Center) (ABIN650621) flow cytometric analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Akari, Bour, Kao et al.: "The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors." in: The Journal of experimental medicine, Vol. 194, Issue 9, pp. 1299-311, 2001 (PubMed).

Akatsuka, Nishida, Kondo et al.: "Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens." in: The Journal of experimental medicine, Vol. 197, Issue 11, pp. 1489-500, 2003 (PubMed).

Validation Images
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