Nephrin antibody (pTyr1193)

Catalog No. ABIN650883

The Rabbit Polyclonal anti-Nephrin antibody (Clone RB28261) (ABIN650883) specifically detects Nephrin in DB. The antibody is reactive with Human samples.

Quick Overview for Nephrin antibody (pTyr1193) (ABIN650883)

Target: Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nephrin antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB28261

Product Details anti-Nephrin Antibody

Binding Specificity: pTyr1193

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Nephrin Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1193 of human Nephrin.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Nephrin

Target: Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))

Alternative Name: Nephrin

Background: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Molecular Weight: 134742

Gene ID: 4868

NCBI Accession: NP_004637

UniProt: O60500

Pathways: Regulation of Actin Filament Polymerization, Skeletal Muscle Fiber Development