IL-8 antibody (C-Term)

Catalog No. ABIN652552

This Rabbit Polyclonal antibody specifically detects IL-8 in WB, FACS, IF and IHC (p). It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for IL-8 antibody (C-Term) (ABIN652552)

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-8 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB20676

Product Details anti-IL-8 Antibody

Binding Specificity: AA 72-99, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This IL8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-99 amino acids from the C-terminal region of human IL8.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-IL-8 antibody (ABIN652552)

Shao, Lu, Zhang, Wang, Li, Hu, Wang, Lin: "Interleukin-8 upregulates integrin ?3 expression and promotes estrogen receptor-negative breast cancer cell invasion by activating the PI3K/Akt/NF-?B pathway." in: Cancer letters, Vol. 364, Issue 2, pp. 165-72, (2015) (PubMed).

Bai, Tai, Li, Zhen, Gu, Jian, Wang, Lin, Zhao, Gong, Liang, Wang, Zhou: "Gankyrin activates IL-8 to promote hepatic metastasis of colorectal cancer." in: Cancer research, Vol. 73, Issue 14, pp. 4548-58, (2013) (PubMed).

Target Details for IL-8

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Alternative Name: IL8

Background: IL8 is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor.

Molecular Weight: 11098

Gene ID: 3576

NCBI Accession: NP_000575

UniProt: P10145

Pathways: TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Hepatitis C, Autophagy