|+1 404 474 4654|
|+1 888 205 9894 (TF)|
T-Box 1 (TBX1) (C-Term) antibody
|Synonyms||DGS, TGA, CAFS, CTHM, DGCR, DORV, VCFS, TBX1C, MGC136724, zgc:136724, mp:zf637-3-000616, TBX1, dgs, tga, cafs, cthm, dgcr, dorv, vcfs, tbx1c, xtbx1|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|4 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334~364 amino acids from the C-terminal region of human TBX1.|
|Description||Other names: Testis-specific T-box protein, T-box transcription factor TBX1, T-box protein 1, TBX1|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334~364 amino acids from the C-terminal region of human TBX1.|
|Molecular Weight||43133 DA|
Background: TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Transcription Factors, Signaling, Neurology|
|Restrictions||For Research Use only|
Yamagishi, Maeda, Hu et al.: "Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer." in: Genes & development, Vol. 17, Issue 2, pp. 269-81, 2003 (PubMed).
Shalaby, Presneau, Idowu et al.: "Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 8, pp. 996-1005, 2009 (PubMed).
Beaujard, Chantot, Dubois et al.: "Atypical deletion of 22q11.2: detection using the FISH TBX1 probe and molecular characterization with high-density SNP arrays." in: European journal of medical genetics, Vol. 52, Issue 5, pp. 321-7, 2009 (PubMed).
Heike, Starr, Rieder et al.: "Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 1, pp. 54-63, 2010 (PubMed).
|Reactivities||Human (29), Mouse (Murine) (21), Rat (Rattus) (20), Chicken (18), Cow (Bovine) (18), Dog (Canine) (18), Horse (Equine) (18), Pig (Porcine) (18)|
|Applications||Immunofluorescence (IF) (18), Western Blotting (WB) (15), ELISA (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)|
|Epitopes||C-Term (3), Internal Region (2), AA 25-41 (1)|