|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Fanconi Anemia, Complementation Group C (FANCC) (C-Term) antibody
|Synonyms||Facc, BB116513, FANCC, zgc:154105, fancc, FA3, FAC, FACC, FLJ14675|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
|4 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529~558 amino acids from the C-terminal region of human FANCC.|
|Description||Other names: Fanconi anemia group C protein, Protein FACC ,FACC, FAC, FANCC|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529~558 amino acids from the C-terminal region of human FANCC.|
|Molecular Weight||63429 DA|
Background: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This protein is for complementation group C.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Sinha, Singh, Alam et al.: "Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma." in: Molecular cancer, Vol. 7, pp. 84, 2009 (PubMed).
Palmieri, Wilson, Iversen et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, 2008 (PubMed).
Michiels, Laplanche, Boulet et al.: "Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk." in: Carcinogenesis, Vol. 30, Issue 5, pp. 763-8, 2009 (PubMed).
McWilliams, Bamlet, de Andrade et al.: "Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2549-52, 2009 (PubMed).
|Hosts||Rabbit (21), Mouse (4)|
|Reactivities||Human (25), Mouse (Murine) (3), Cat (Feline) (1), Chicken (1), Chimpanzee (1), Cow (Bovine) (1), Dog (Canine) (1), Monkey (1), Rat (Rattus) (1)|
|Applications||Western Blotting (WB) (25), ELISA (14), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Immunofluorescence (IF) (7), Immunocytochemistry (ICC) (5), Immunohistochemistry (IHC) (5), Immunoprecipitation (IP) (2), Flow Cytometry (FACS) (1)|
|Epitopes||AA 96-112 (2), C-Term (2), AA 1-101 (1), AA 1-558 (1)|