gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (C-Term) antibody

Antigen: gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2)

Synonyms: HG20, GPR51, GPRC3B, GABABR2, FLJ36928, HRIHFB2099, GABA(B)R2

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654172

Additional Information

Alternative name: GABBR2

Gene ID: 9568

UniProt: O75899, NP_005449.5

Immunogen: This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 868-898 amino acids from the C-terminal region of human GABBR2.

Isotype: Ig

Description: Other names: Gamma-aminobutyric acid type B receptor subunit 2,GABBR2,GPR51, GPRC3B

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 868-898 amino acids from the C-terminal region of human GABBR2.

Molecular Weight: 105821 DA

Comments:

Background: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology

Restrictions: For Research Use only

Images

GABBR2 antibody (C-term) (ABIN654172) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GABBR2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Oblak, Gibbs, Blatt: "Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism." in: Journal of neurochemistry, Vol. 114, Issue 5, pp. 1414-23, 2010 (PubMed).