Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) (Center) antibody

Antigen: Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2)

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654466

Additional Information

Alternative name: MCAF2

Gene ID: 80063

UniProt: Q5U623, NP_079273.2

Immunogen: This MCAF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-355 amino acids from the Central region of human MCAF2.

Isotype: Ig

Description: Other names: ATF7IP2,Activating transcription factor 7-interacting protein 2,MCAF2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This MCAF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-355 amino acids from the Central region of human MCAF2.

Molecular Weight: 75764 DA

Comments:

Background: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone 'Lys-9' trimethylation activity (Probable).

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Ichimura, Watanabe, Sakamoto et al.: "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13928-35, 2005 (PubMed).