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H2A Histone Family, Member Y2 (H2AFY2) (AA 11-39), (N-Term) antibody

Details for Product No. ABIN654683, Supplier: Login to see
Antigen
  • RGD1561371
  • MGC69037
  • MGC130768
  • macroh2a2
  • im:6898017
  • wu:fa14g05
  • zgc:114051
  • macroH2A2
Epitope
AA 11-39, N-Term
16
16
16
4
3
3
3
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
58
8
5
Host
Rabbit
42
16
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Western Blotting (WB)
50
18
14
5
5
2
1
1
Supplier
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Immunogen This H2AFY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 AA from the N-terminal region of human H2AFY2.
Clone RB28554
Isotype Ig
Specificity This H2AFY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human H2AFY2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name H2AFY2 (H2AFY2 Antibody Abstract)
Background Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Synonyms: Core histone macro-H2A.2,H2AFY2,MACROH2A2
Molecular Weight 40058 DA
Gene ID 55506
NCBI Accession NP_061119
UniProt Q9P0M6
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Pathways
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Flow Cytometry (FACS) image for anti-H2A Histone Family, Member Y2 (H2AFY2) (AA 11-39), (N-Term) antibody (ABIN654683) H2AFY2 Antibody (N-term) (ABIN654683) flow cytometric analysis of Hela cells (right h...
Background publications Xu, Zheng, Isaacs et al.: "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2136-40, 2010 (PubMed).

Sporn, Kustatscher, Hothorn et al.: "Histone macroH2A isoforms predict the risk of lung cancer recurrence." in: Oncogene, Vol. 28, Issue 38, pp. 3423-8, 2009 (PubMed).

Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).