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Inhibin, beta B (INHBB) (AA 369-397), (C-Term) antibody

Details for Product No. ABIN655083, Supplier: Log in to see
Antigen
  • actbb
  • actbetaB
  • inhibin
Epitope
AA 369-397, C-Term
16
13
10
10
10
2
2
2
1
1
1
1
1
1
Reactivity
Mouse (Murine)
73
44
31
18
11
4
4
2
2
2
1
Host
Rabbit
106
9
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
20
14
7
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
74
69
31
12
10
8
7
1
1
1
1
1
Supplier
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Immunogen This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-397 AA from the C-terminal region of human INHBB.
Clone RB23814
Isotype Ig
Specificity This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human INHBB.
Predicted Reactivity Cow (Bovine),Chicken,Pig (Porcine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name INHBB (INHBB Antibody Abstract)
Background The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Synonyms: Inhibin beta B chain,INHBB,
Molecular Weight 45122 DA
Gene ID 3625
NCBI Accession NP_002184
UniProt P09529
Research Area Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Inhibin, beta B (INHBB) (AA 369-397), (C-Term) antibody (ABIN655083) INHBB Antibody (C-term) (ABIN655083) immunohistochemistry analysis in formalin fixed ...
Background publications Canzian, Cox, Setiawan et al.: "Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3873-84, 2010 (PubMed).