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Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (C-Term) antibody
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|UniProt||P42574, NP_004337.2, NP_116786.1|
|Immunogen||This CASP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-256 amino acids from the C-terminal region of human CASP3.|
|Description||Other names: Caspase-3,CASP3,CPP32|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This CASP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-256 amino acids from the C-terminal region of human CASP3.|
|Molecular Weight||31608 DA|
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].
|Synonyms||CC3, Lice, Yama, CPP32, Apopain, Caspase-3, A830040C14Rik, Cas3, Casp3, DECAY, Drosophila executioner caspase related to Apopain/Yama, caspase 3, DmelCG14902, CG14902, DRICE, ICE, DmelCG7788, CG7788, casp3, xcpp32, CASP3|
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure|
|Restrictions||For Research Use only|
Burke, Smith, Smith: "cIAP1 cooperatively inhibits procaspase-3 activation by the caspase-9 apoptosome." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 30061-8, 2010 (PubMed).
Würstle, Laussmann, Rehm: "The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33209-18, 2010 (PubMed).
Srikanth, Wall, Maldonado-Contreras et al.: "Salmonella pathogenesis and processing of secreted effectors by caspase-3." in: Science (New York, N.Y.), Vol. 330, Issue 6002, pp. 390-3, 2010 (PubMed).