KCNQ1 antibody (N-Term)

Catalog No. ABIN656077

This Rabbit Polyclonal antibody specifically detects KCNQ1 in WB. It exhibits reactivity toward Human.

Quick Overview for KCNQ1 antibody (N-Term) (ABIN656077)

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNQ1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB31015

Product Details anti-KCNQ1 Antibody

Binding Specificity: AA 4-33, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KCNQ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of human KCNQ1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for KCNQ1

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Alternative Name: KCNQ1

Background: This gene encodes a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a number of contiguous genes, which are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. This gene is also imprinted, with preferential expression from the maternal allele in some tissues, excluding cardiac muscle. Alternatively spliced transcripts encoding distinct isoforms have been described.

Molecular Weight: 74699

Gene ID: 3784

NCBI Accession: NP_000209

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound