Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) (Center) antibody

Antigen: Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1)

Synonyms: DVL, MGC54245, KIAA0208, MGC114008, wu:fb75f04, wu:fi22h02, wu:fp61b09, MGC82074, dvl3, dsh3, Dvl, KIAA4029, mKIAA4029, dvl-1, DVL1, DSH, DVL-1

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656260

Additional Information

Alternative name: DVL1

Gene ID: 1855

UniProt: NP_004412.2, O14640

Immunogen: This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from the Central region of human DVL1.

Isotype: Ig

Description: Other names: DVL1,Segment polarity protein dishevelled homolog DVL-1,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from the Central region of human DVL1.

Molecular Weight: 75187 DA

Comments:

Background: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: DVL1 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

Confocal immunofluorescent analysis of DVL1 Antibody (Center) (ABIN656260) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Publications

Product: Varelas, Miller, Sopko et al.: "The Hippo pathway regulates Wnt/beta-catenin signaling." in: Developmental cell, Vol. 18, Issue 4, pp. 579-91, 2010 (PubMed).