DVL1 antibody (AA 442-470)

Catalog No. ABIN656260

This Rabbit Polyclonal antibody specifically detects DVL1 in WB, IF and IHC (p). It exhibits reactivity toward Human and Mouse.It has been mentioned in 1 publication

Quick Overview for DVL1 antibody (AA 442-470) (ABIN656260)

Target: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DVL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB31716

Product Details anti-DVL1 Antibody

Binding Specificity: AA 442-470

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. IF: 1:25. WB: 1:1000. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-DVL1 antibody (ABIN656260)

Bunn, Daniel, Rösken, ONeill, Cameron-Christie, Morgan, Brunner, Lai, Kunst, Markie, Robertson: "Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome." in: American journal of human genetics, Vol. 96, Issue 4, pp. 623-30, (2015) (PubMed).

Target Details for DVL1

Target: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Alternative Name: DVL1

Background: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

Molecular Weight: 75187

Gene ID: 1855

NCBI Accession: NP_004412

UniProt: O14640

Pathways: WNT Signaling, Synaptic Membrane, Skeletal Muscle Fiber Development