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FCN3 antibody (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen)) (AA 214-243)

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Antigen
Synonyms FCNH, HAKA1
Alternatives
Epitope
AA 214-243, C-Term
(16), (15), (6), (5), (4), (3), (1), (1)
Reactivity
Human
(40)
Host
Rabbit
(36), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
This FCN3 antibody is un-conjugated
(3), (3), (2), (2), (2), (2)
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(36), (25), (14), (14), (4), (2), (2), (2), (1)
Pubmed 3 references available
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Quantity 400 μL
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Immunogen This FCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-243 AA from the C-terminal region of human FCN3.
Clone RB31101
Isotype Ig
Specificity This FCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-243 amino acids from the C-terminal region of human FCN3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FCN3 (FCN3 Antibody Abstract)
Background Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Synonyms: Ficolin-3,FCN3,FCNH, HAKA1
Molecular Weight 32903 DA
Gene ID 8547
NCBI Accession NP_003656, NP_775628
UniProt O75636
Research Area Cell Signaling, Protein Modifications, Cell Structure
Pathways Complement System
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.27 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment FCN3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FCN3 antibody (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen)) (AA 214-243) (ABIN656492) FCN3 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).T...
Immunohistochemistry (IHC) image for anti-FCN3 antibody (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen)) (AA 214-243) (ABIN656492) FCN3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin e...
Flow Cytometry (FACS) image for anti-FCN3 antibody (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen)) (AA 214-243) (ABIN656492) FCN3 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) comp...
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Lacroix, Dumestre-Pérard, Schoehn et al.: "Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 1, pp. 456-65, 2008 (PubMed).

Munthe-Fog, Hummelshøj, Ma et al.: "Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state." in: Molecular immunology, Vol. 45, Issue 9, pp. 2660-6, 2008 (PubMed).

Catalog No. ABIN656492
$324.50
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