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BPGM antibody (2,3-bisphosphoglycerate Mutase) (AA 230-259)

Details for Product anti-BPGM Antibody No. ABIN656546, Supplier: Log in to see
Antigen
  • DPGM
  • AI323730
  • AL022789
  • C86192
  • Ab2-098
  • zgc:92230
  • Bisphosphoglycerate mutase
  • 2,3-bisphosphoglycerate mutase
  • pmge
  • BPGM
  • Bpgm
  • bpgm
Epitope
AA 230-259, C-Term
21
15
2
2
2
2
1
1
1
1
1
Reactivity
Human
68
28
25
3
3
2
2
2
1
1
1
1
1
1
Host
Rabbit
67
2
Clonality (Clone)
Polyclonal ()
Conjugate
This BPGM antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
55
23
13
10
8
8
6
2
2
2
1
Options
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Immunogen This BPGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-259 AA from the C-terminal region of human BPGM.
Clone RB32095
Isotype Ig
Specificity This BPGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-259 amino acids from the C-terminal region of human BPGM.
Predicted Reactivity Monkey
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BPGM (BPGM Antibody Abstract)
Background 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms: Bisphosphoglycerate mutase,BPGM,
Molecular Weight 30005 DA
Gene ID 669
NCBI Accession NP_001715, NP_954655
UniProt P07738
Research Area Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment BPGM Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BPGM antibody (2,3-bisphosphoglycerate Mutase) (AA 230-259) (ABIN656546) BPGM Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/la...
Western Blotting (WB) image for anti-BPGM antibody (2,3-bisphosphoglycerate Mutase) (AA 230-259) (ABIN656546) Western blot analysis of BPGM (arrow) using rabbit polyclonal BPGM Antibody (C-term) ...
Background publications Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Wang, Liu, Wei, Cheng, Lin, Gong: "Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase." in: The Journal of biological chemistry, Vol. 281, Issue 51, pp. 39642-8, 2006 (PubMed).

Wang, Wei, Bian, Cheng, Wan, Liu, Gong: "Crystal structure of human bisphosphoglycerate mutase." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 39132-8, 2004 (PubMed).

Fujita, Suzuki, Tada, Yoshihara, Hamaoka, Uchida, Matuo, Sasaki, Hanafusa, Taniguchi: "Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro." in: Journal of biochemistry, Vol. 124, Issue 6, pp. 1237-44, 1999 (PubMed).