Single-Minded Homolog 1 (Drosophila) (SIM1) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN656884
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Antigen
Synonyms bHLHe14, mSIM1
Epitope
N-Term, AA 1-30
(10), (9), (4), (1)
Reactivity
Human
(30), (14), (14), (14), (14), (14), (13), (1)
Host
Rabbit
(26), (3), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(19), (10), (10), (10), (6), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN656884
238.50 $
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Immunogen This SIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human SIM1.
Clone RB32160
Isotype Ig
Specificity This SIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SIM1.
Predicted Reactivity Fruit Fly (Drosophila melanogaster),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SIM1
Background SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome.
Synonyms: Single-minded homolog 1,SIM1,BHLHE14
Molecular Weight 85515 DA
Gene ID 6492
NCBI Accession NP_005059
UniProt P81133
Research Area Cell Cycle, Transcription Factors, Signaling, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SIM1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Single-Minded Homolog 1 (Drosophila) (SIM1) (N-Term), (AA 1-30) antibody SIM1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SIM1 antibody detected the SIM1 protein (arrow).
anti-Single-Minded Homolog 1 (Drosophila) (SIM1) (N-Term), (AA 1-30) antibody (2) SIM1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SIM1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Traurig, Mack, Hanson et al.: "Common variation in SIM1 is reproducibly associated with BMI in Pima Indians." in: Diabetes, Vol. 58, Issue 7, pp. 1682-9, 2009 (PubMed).

Validation Images
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