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Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) (AA 15-44), (N-Term) antibody

Details for Product No. ABIN656896, Supplier: Log in to see
Antigen
  • BRESEK
  • IFAP
  • KFSDX
  • S2P
  • 9630032G22Rik
  • AI662535
  • LRRGT00063
Epitope
AA 15-44, N-Term
16
15
4
2
2
1
1
1
1
Reactivity
Human
31
8
7
2
Host
Rabbit
28
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
24
23
14
8
2
1
1
Supplier
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Immunogen This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 AA from the N-terminal region of human MBTPS2.
Clone RB32439
Isotype Ig
Specificity This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human MBTPS2.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MBTPS2 (MBTPS2 Antibody Abstract)
Background This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.
Synonyms: Membrane-bound transcription factor site-2 protease,MBTPS2,S2P
Molecular Weight 57444 DA
Gene ID 51360
NCBI Accession NP_056968
UniProt O43462
Research Area Protein Modifications, Cell Structure, Metabolism
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MBTPS2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) (AA 15-44), (N-Term) antibody (ABIN656896) MBTPS2 Antibody (N-term) (ABIN656896) immunohistochemistry analysis in formalin fixed...
Background publications Lee, Tirasophon, Shen et al.: "IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response." in: Genes & development, Vol. 16, Issue 4, pp. 452-66, 2002 (PubMed).

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