AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) (N-Term), (AA 52-80) antibody

Details for Product No. ABIN657143
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Antigen
Synonyms MGC147390, si:ch211-12e1.4, SCA28, SPAX5, 2310036I02Rik, AW260507, Emv66, par
Epitope
N-Term, AA 52-80
(7), (7), (1), (1), (1), (1)
Reactivity
Human
(39), (16), (16), (13), (13), (13), (12), (1), (1)
Host
Rabbit
(37), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(30), (20), (13), (10), (5), (2), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN657143
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Immunogen This AFG3L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 AA from the N-terminal region of human AFG3L2.
Clone RB33011
Isotype Ig
Specificity This AFG3L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the N-terminal region of human AFG3L2.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AFG3L2
Background This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
Synonyms: AFG3-like protein 2,AFG3L2,
Research Area Signaling, Protein Modifications, Cell Structure, Chromatin, Neurology, Metabolism
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) (N-Term), (AA 52-80) antibody AFG3L2 Antibody (N-term) western blot analysis in MDA-MB453,MCF-7,Jurkat cell line lysates (35ug/lane).This demonstrates the AFG3L2 antibody detected the AFG3L2 protein (arrow).
anti-AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) (N-Term), (AA 52-80) antibody (2) AFG3L2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AFG3L2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Augustin, Gerdes, Lee et al.: "An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases." in: Molecular cell, Vol. 35, Issue 5, pp. 574-85, 2009 (PubMed).

Di Bella, Lazzaro, Brusco et al.: "Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28." in: Nature genetics, Vol. 42, Issue 4, pp. 313-21, 2010 (PubMed).

Edener, Wöllner, Hehr et al.: "Early onset and slow progression of SCA28, a rare dominant ataxia in a large four-generation family with a novel AFG3L2 mutation." in: European journal of human genetics : EJHG, Vol. 18, Issue 8, pp. 965-8, 2010 (PubMed).

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