AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) (N-Term) antibody

Antigen: AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2)

Synonyms: SCA28, FLJ25993, par, Emv66, AW260507, 2310036I02Rik, MGC109579, MGC127067, MGC147390

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657143

Additional Information

Alternative name: AFG3L2

Isotype: Ig

Description: Other names: AFG3-like protein 2,AFG3L2,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This AFG3L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the N-terminal region of human AFG3L2.

Comments:

Background: This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.

Application Details

Concentration: 0.25 mg/ml

Purification: Purified

Research Area: Signaling, Protein Modifications, Cell Structure, Chromatin, Neurology, Metabolism

Restrictions: For Research Use only

Publications

Product: Augustin, Gerdes, Lee et al.: "An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases." in: Molecular cell, Vol. 35, Issue 5, pp. 574-85, 2009 (PubMed).

Di Bella, Lazzaro, Brusco et al.: "Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28." in: Nature genetics, Vol. 42, Issue 4, pp. 313-21, 2010 (PubMed).

Edener, Wöllner, Hehr et al.: "Early onset and slow progression of SCA28, a rare dominant ataxia in a large four-generation family with a novel AFG3L2 mutation." in: European journal of human genetics : EJHG, Vol. 18, Issue 8, pp. 965-8, 2010 (PubMed).