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Amyloid beta (A4) Precursor Protein (APP) (Center) antibody

Antigen

Amyloid beta (A4) Precursor Protein (APP)
Synonyms APP, APP-like, APPL, Abeta, BcDNA:GH04413, EG:65F1.5, DmelCG7727, CG7727, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma, aaa, ad1, pn2, abpp, appi, cvap, abeta, MGC88882, ctfgamma
Binding Site
Alternatives

Center
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN657612
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-Amyloid beta (A4) Precursor Protein (APP) (Center) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name APP
Gene ID 351
UniProt P05067, NP_958816.1, NP_000475.1, NP_001129601.1, NP_001129602.1
Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
Isotype Ig
Description Other names: Amyloid beta A4 protein,APP,A4, AD1
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
Molecular Weight 79kd Isoform. 86943 DA
Comments

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage APP Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Restrictions For Research Use only

Publications
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Product Singh, Park, Bae et al.: "MEGF10 functions as a receptor for the uptake of amyloid-β." in: FEBS letters, Vol. 584, Issue 18, pp. 3936-42, 2010 (PubMed).

Crews, Adame, Patrick et al.: "Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 37, pp. 12252-62, 2010 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts Rabbit (232), Mouse (72), Goat (34), Chicken (3)
Reactivities Human (297), Mouse (Murine) (120), Rat (Rattus) (114), Cow (Bovine) (75), Dog (Canine) (68), Chicken (65), Pig (Porcine) (65), Horse (Equine) (56), Sheep (Ovine) (5), Monkey (4), Xenopus laevis (2), Zebrafish (2), Cat (Feline) (1), Fruit Fly (Drosophila melanogaster) (1), Rabbit (1)
Applications Western Blotting (WB) (236), ELISA (129), Immunofluorescence (IF) (85), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (75), Immunohistochemistry (IHC) (67), Immunoprecipitation (IP) (25), Flow Cytometry (FACS) (12), Immunohistochemistry (Fixed) (IHC (fx)) (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (8), ELISA (Detection) (3), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Dot Blot (Dot) (2), Immunocytochemistry (ICC) (2), Immunoelectron Microscopy (IEM) (2), ELISA (Capture) (1), Enzyme Immunoassay (EIA) (1)
Conjugates Alexa Fluor 350 (8), Alexa Fluor 488 (8), Alexa Fluor 555 (8), Alexa Fluor 647 (8), PE,Cy5.5 (8), Biotin (6), FITC (4), HRP (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2)
Epitopes N-Term (30), C-Term (26), pThr668 (12), Transcript Variant 1 (10), pThr743 (9), pSer198 (7), pSer730 (7), pTyr757 (5), AA 44-63 (4), AA 737-751 (4), AA 292-312 (3), C-Term,AA 1-40 (3), Internal Region (3), Thr668 (3), pTyr756 (3), AA 1-14 (2), AA 18-289 (2), AA 653-662 (2), AA 660-669 (2), AA 681-695 (2), AA 747-761 (2), Frameshift Mutant (2), KPI Domain (2), AA 1-16 (1), AA 1-43 (1), AA 339-348 (1), AA 350-450 (1), AA 36-42 (1), AA 671-685 (1), AA 73-7 (1), C-Term,AA 1-42 (1), C-Term,Asp672 (1), Extracellular Domain (1), Frameshift Mutant, AA 339-348 (1), Frameshift Mutant, C-Term (1), N-Term,AA 1-43 (1), N-Term,AA 18-32 (1), OX-2 Domain (1), Precursor, AA 653-662 (1), Precursor, C-Term, AA 737-751 (1), Ser730 (1), Thr743, Thr668 (1), Tyr756 (1), Wild Type (1), all Isoforms (1), pSer129 (1), pSer182 (1), pSer264 (1), pSer347 (1), pSer498,pSer490 (1), pThr743, pThr668 (1), pThr743,pThr668 (1)