Histone Cluster 2, H2ab (Hist2h2ab) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN657626
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Antigen
Synonyms h2a, H2AB, EG621893, H2a-613a
Epitope
N-Term, AA 1-30
(7), (7)
Reactivity
Human
(7)
Host
Rabbit
(7)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(7), (6)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN657626
291.50 $
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Immunogen This HIST2H2AB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human HIST2H2AB.
Clone RB33635
Isotype Ig
Specificity This HIST2H2AB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST2H2AB.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HIST2H2AB
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.
Synonyms: Histone H2A type 2-B,HIST2H2AB,
Molecular Weight 13995 DA
Gene ID 317772
NCBI Accession NP_778235
UniProt Q8IUE6
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment HIST2H2AB Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Histone Cluster 2, H2ab (Hist2h2ab) (N-Term), (AA 1-30) antibody HIST2H2AB Antibody (N-term) (ABIN657626) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the HIST2H2AB antibody detected the HIST2H2AB protein (arrow).
Background publications Aihara, Nakagawa, Yasui et al.: "Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo." in: Genes & development, Vol. 18, Issue 8, pp. 877-88, 2004 (PubMed).

Wang, Wang, Erdjument-Bromage et al.: "Role of histone H2A ubiquitination in Polycomb silencing." in: Nature, Vol. 431, Issue 7010, pp. 873-8, 2004 (PubMed).

Hagiwara, Hidaka, Yamada: "Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes." in: Biochemistry, Vol. 44, Issue 15, pp. 5827-34, 2005 (PubMed).

Cao, Tsukada, Zhang: "Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing." in: Molecular cell, Vol. 20, Issue 6, pp. 845-54, 2005 (PubMed).

Bergink, Salomons, Hoogstraten et al.: "DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A." in: Genes & development, Vol. 20, Issue 10, pp. 1343-52, 2006 (PubMed).

Validation Images
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