Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) (C-Term) antibody

Antigen: Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1)

Synonyms: NFAT2, NFATc, NF-ATC, MGC138448, NF-ATc, Nfatcb, AI449492, AV076380, 2210017P03Rik, nfat2, nfatc, nf-atc, MGC82799, NFATC1, NFAT, NF-ATc1, si:ch211-198c22.2, MGC146167

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657821

Additional Information

Alternative name: NFATC1

Gene ID: 4772

UniProt: NP_765977.1, NP_765978.1, NP_765975.1, NP_006153.2

Immunogen: This NFATC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 897-927 amino acids from the C-terminal region of human NFATC1.

Isotype: Ig

Description: Other names: Nuclear factor of activated T-cells, cytoplasmic 1,NFATC1,NFAT2, NFATC

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This NFATC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 897-927 amino acids from the C-terminal region of human NFATC1.

Molecular Weight: 101243 DA

Comments:

Background: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: NFATC1 Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

NFATC1 Antibody (C-term) (ABIN657821) western blot analysis in NCI-H292 cell line lysates (35ug/lane). This demonstrates the NFATC1 antibody detected the NFATC1 protein (arrow).

Publications

Product: Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).