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HES1 (N-Term) antibody
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HES1.|
|Description||Other names: Transcription factor HES-1,3280,BHLHB39, HL, HRY|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HES1.|
|Molecular Weight||29541 DA|
Background: This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||HES1 Antibody (N-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure|
|Restrictions||For Research Use only|
|HES1 Antibody (N-term) (ABIN657944) western blot analysis in U251 cell line lysates (35ug/lane). This demonstrates the HES1 antibody detected the HES1 protein (arrow).|
Sang, Roberts, Coller: "Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells." in: Trends in molecular medicine, Vol. 16, Issue 1, pp. 17-26, 2010 (PubMed).
Wang, Fu, Chen et al.: "The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 7, pp. 989-96, 2010 (PubMed).
Espinosa, Cathelin, DAltri et al.: "The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia." in: Cancer cell, Vol. 18, Issue 3, pp. 268-81, 2010 (PubMed).