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CUGBP, Elav-Like Family Member 1 (CELF1) (AA 1-30), (N-Term) antibody

Details for Product No. ABIN657957, Supplier: Log in to see
Antigen
  • CUGBP1
  • BRUNOL2
  • CUG-BP
  • CUGBP
  • EDEN-BP
  • NAB50
  • NAPOR
  • hNab50
  • 1600010O03Rik
  • AA407467
  • Brunol2
  • CUG-BP1
  • Cugbp1
  • D2Wsu101e
  • HNAB50
  • Bruno-like
  • brul
  • cb920
  • cugbp1
  • brunol2
  • cug-bp
  • cug-bp1
  • cugbp
  • cugbp1-a
  • eden-bp
  • edenbp
  • nab50
Epitope
AA 1-30, N-Term
20
16
3
3
3
1
1
1
1
1
1
1
Reactivity
Human
59
23
20
2
2
2
1
1
Host
Rabbit
50
9
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
49
26
26
9
4
4
2
1
1
Supplier
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Immunogen This CUGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human CUGBP1.
Clone RB34074
Isotype Ig
Specificity This CUGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CUGBP1.
Predicted Reactivity Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CUGBP1 (CELF1 Antibody Abstract)
Background Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: CUGBP Elav-like family member 1,10658,BRUNOL2, CUGBP, CUGBP1, NAB50
Molecular Weight 52063 DA
Gene ID 10658
NCBI Accession NP_001166110, NP_001166111, NP_941989, NP_001020767
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CUGBP1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CUGBP, Elav-Like Family Member 1 (CELF1) (AA 1-30), (N-Term) antibody (ABIN657957) CUGBP1 Antibody (N-term) (ABIN657957) western blot analysis in ZR-75-1 cell line lysa...
Background publications Le Tonquèze, Gschloessl, Namanda-Vanderbeken et al.: "Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation." in: Biochemical and biophysical research communications, Vol. 394, Issue 4, pp. 884-9, 2010 (PubMed).

Koshelev, Sarma, Price et al.: "Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1." in: Human molecular genetics, Vol. 19, Issue 6, pp. 1066-75, 2010 (PubMed).

Tsuda, Kuwasako, Takahashi et al.: "Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3." in: Nucleic acids research, Vol. 37, Issue 15, pp. 5151-66, 2009 (PubMed).